PDGF-B Antibody

Cat no: 250815

Supplier: ABBIOTEC

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Description
Additional Information

Platelet-derived growth factor (PDGF-A and PDGF-B subunits) is a potent mitogen for cells of mesenchymal origin. Binding of PDGF to its receptor PDGFR triggers a variety of cellular responses. PDGF is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and heal the wound. PDGF consists of antiparallel disulfide-linked dimer of non identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. A-A and B-B homodimers as well as A-B heterodimers bind to the PDGF receptor. A chromosomal aberration involving PDGF-B is a cause of dermatofibrosarcoma protuberans (DFSP), an uncommon aggressive tumor of the deep dermis and subcutaneous tissue. PDGF-B is available under the name Regrane, Xenopus/Amphibian, (Ortho-McNeil) to promote healing in diabetic neuropathic foot ulcers.

Catalogue number:	250815
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P01127
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PDGF-B.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Platelet-derived growth factor subunit B; PDGF subunit B; Platelet-derived growth factor B chain; Platelet-derived growth beta polypeptide; PDGF-2; c-sis; Becaplermin; PDGFB; PDGF2; SIS