Home  >  Products  >  PDIA6, aa20-440, Recombinant, Human (Protein Disulfide-isomerase A6, ERP5, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, P5, TXNDC7)

PDIA6, aa20-440, Recombinant, Human (Protein Disulfide-isomerase A6, ERP5, Endoplasmic Reticulum Protein 5, ER Protein 5, ERp5, Protein Disulfide Isomerase P5, Thioredoxin Domain-containing Protein 7, P5, TXNDC7)

Cat no: P3122-36M


Supplier: United States Biological
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PDIA6 is a member of the protein disulfide isomerase (PDI). PDI is an enzyme in the endoplasmic reticulum in eukaryotes or periplasmic space of prokaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. PDIA6 function as a chaperone that inhibits aggregation of misfolded proteins. It plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Source: Recombinant corresponding to aa20-440 of human PDIA6 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MLYSSSDDVI ELTPSNFNRE VIQSDSLWLV EFYAPWCGHC QRLTPEWKKA ATALKDVVKV GAVDADKHHS LGGQYGVQGF PTIKIFGSNK NRPEDYQGGR TGEAIVDAAL SALRQLVKDR LGGRSGGYSS GKQGRSDSSS KKDVIELTDD SFDKNVLDSE DVWMVEFYAP WCGHCKNLEP EWAAAASEVK EQTKGKVKLA AVDATVNQVL ASRYGIRGFP TIKIFQKGES PVDYDGGRTR SDIVSRALDL FSDNAPPPEL LEIINEDIAK RTCEEHQLCV VAVLPHILDT GAAGRNSYLE VLLKLADKYK KKMWGWLWTE AGAQSELETA LGIGGFGYPA MAAINARKMK FALLKGSFSE QGINEFLREL SFGRGSTAPV GGGAFPTIVE REPWDGRDGE LPVEDDIDLS DVELDDLGKD EL Molecular Weight: 48.5kD (442aa) confirmed by MALDI-TOF Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P3122-36M
Size: 100ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol, 2mM DTT, 50mM sodium chloride.
Purity: ~90% (SDS-PAGE).
References: 1. Jordan P.A., et al. (2005) Blood 105:1500-1507. 2. Kikuchi M., et al. (2002) J. Biochem. 132:451-455.

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