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PDRG1, aa1-133, Recombinant, Human (p53 and DNA-damage Regulated 1, C20orf126, PDRG)

Cat no: P3125-70H


Supplier: United States Biological
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PDRG1, also known as PDRG or C20orf126, is a 133aa protein that localizes to the cytoplasm and belongs to the prefoldin subunit b family. Expressed predominately in normal testicular tissue, PDRG1 is functionally induced by ultraviolet light and is thought to play a role in chaperone-mediated protein folding, possibly playing a role in cellular degradation. It is associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Source: Recombinant corresponding to aa1-133 of human PDRG1 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD LSLSEDVMVC FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN RLFEAQGKPE LKGFNLNPLN QDELKALKVI LKG Molecular Weight: 17.6kD (153aa) confirmed by MALDI-TOF Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P3125-70H
Size: 100ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.2M sodium chloride, 5mM DTT, 20% glycerol.
Purity: ~90% (SDS-PAGE).
References: 1. Russell RB., et al. (2008) Nat Chem Biol. 4(11):666-73. 2. Luo X., et al. (2003) Oncogene. 22(46):7247-57.

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