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PE anti-human CD254 (TRANCE, RANKL)

PE anti-human CD254 (TRANCE, RANKL)

Cat no: 347504

Supplier: BioLegend
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Human RANKL (receptor activator of NF-kB ligand), known as Trance (TNF-related activation-induced cytokine receptor) and OPGL (Osteoprotegerin ligand), or CD254, is a type II transmembrane protein in TNF superfamily that has two forms-a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. TRANCE is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of the interactions between T cells and dendritic cells. RANKL plays an important role in osteoclast differentiation and bone resorption. Trance activates JNK and NF-kappaB and induces the expression of IL-1, IL-6, IL-12, IL-15 in dendritic cells.
Catalogue number: 347504
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 tests
Clone: MIH24
Gene: 8600
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microl to 5 microl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microl staining volume or per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen: RANKL-transfected L cells
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TNF-related activation-induced cytokine receptor (TRANCE), CD254, RANK-L, OPGL, SOFA, TNFSF-11
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