PE anti-human CD255 (TWEAK)

Cat no: 308305

Supplier: BioLegend

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TNF-like weak inducer of apoptosis (TWEAK) is a type II transmembrane TNF superfamily member with strong homology to TNF in its extracellular portion, though less potent in inducing apoptosis. It has been clustered as CD255. TWEAK transcript is expressed broadly in many adult and fetal tissues; however, the staining of human peripheral blood mononuclear cells with TWEAK-specific antibodies shows a more restricted pattern. TWEAK is expressed as membrane-bound and secreted forms. Interaction of TWEAK with its receptors (DR3, Fn14) promotes secretion of IL-8, activation of NF-kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines.

Catalogue number:	308305
Reactivities:	Human
Hosts:	Mouse
Applications:	Flow Cytometry
Size:	25 tests
Clone:	CARL-1
Gene:	8742
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microl to 5 microl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microl staining volume or per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
Storage buffer:	The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen:	hTWEAK/2PK-3 transfectant cells
Isotype:	Mouse IgG3, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	TNF-like weak inducer of apoptosis, Apo-3 ligand, DR3-L, TNFSF-12

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PE anti-human CD255 (TWEAK)

Cat no: 308305

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