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PE anti-human CD334 (FGFR4)

PE anti-human CD334 (FGFR4)

Cat no: 324306

Supplier: BioLegend
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The 4FR6D3 antibody recognizes human CD334, also known as fibroblast growth factor 4, FGFR4 and TKF. CD334 is a member of the fibroblast growth factor receptor family and a cell surface tyrosine kinase containing three immunoglobulin-like domains. FGFR4 has a predicted molecular weight of approximately 88 kD and is widely expressed in many tissues including the intestine, muscle, heart, cornea, retina, and pancreas, with highest expression in lung and kidney.CD334 binds acidic fibroblast growth factors (FGF8, GFG1, FGF19, FGF6, and FGF2); ligand binding induces mitogenesis and differentiation. CD334 has been shown to interact with STAT1 and STAT3 and is over-expressed in gynecological tumors suggesting a possible role for this receptor in breast and ovarian tumorigenesis. Unique alleles (Arg388) in FGFR4 have been shown to be associated with cancer progression and increased tumor cell motility. The 4FR6D3 antibody has been shown to be useful for flow cytometry.
Catalogue number: 324306
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 tests
Clone: 4FR6D3
Gene: 2264
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microl to 5 microl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microl staining volume or per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen: NIH-3T3 cells transfected with full-length human FGFR4
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: FGFR4, FGF-R4, TKF
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