CD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). CD85a is the 110kD member, known as ILT5, LIR-3, or HL9. ILT5 structurally has four extracellular Ig domains and 4 ITIMs in its cytoplasmic tail that provide inhibitory signals. ILT5 is found on the surface of Monocytes/macrophages, granulocytes, NK cells and T-cell subset. ILT5 provides inhibitory signals through interaction with MHC class I molecules.