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PE anti-mouse B7-H4 (B7S1, B7X)

PE anti-mouse B7-H4 (B7S1, B7X)

Cat no: 128107

Supplier: BioLegend
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B7-H4 is a newly discovered B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. A new function of B7-H4 was reported as an important negative regulator of innate immunity through growth inhibition of neutrophils. It was reported that B7-H4 does not constitutively expressed on peripheral tissues but could be induced to express on T cells, B cells, macrophages, and dendritic cells. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. Although B- and T- lymphocyte attenuator (BTLA) was proposed to be the receptor for B7-H4, further studies are needed to identify the inhibitory receptor of B7-H4.
Catalogue number: 128107
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 50 microg
Clone: clone 9
Gene: 242122
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.06 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.2 mg/ml
Antigen: B7-S1 Fc fusion protein
Isotype: Rat IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: B7S1, B7H4, B7-S1, B7x
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