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PE anti-mouse CD124 (IL-4Ralpha)

PE anti-mouse CD124 (IL-4Ralpha)

Cat no: 144803

Supplier: BioLegend
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CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common gamma-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Ralpha exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B-cells, T-cells, monocytes, and has low expression on granulocytes. In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.
Catalogue number: 144803
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 25 microg
Clone: I015F8
Gene: 4684
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.2 mg/ml
Antigen: mIL4Ra Fc
Isotype: Rat IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: IL-4 receptor alpha subunit (IL-4Ra, IL4Ra), IL-4R (IL4R)
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