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PE anti-mouse CD270 (HVEM)

PE anti-mouse CD270 (HVEM)

Cat no: 136304

Supplier: BioLegend
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Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTalpha, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.
Catalogue number: 136304
Reactivities: Mouse
Applications: Flow Cytometry
Size: 100 microg
Clone: HMHV-1B18
Gene: 208154
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.2 mg/ml
Antigen: Mouse HVEM-hIgG1Fc fusion protein
Isotype: Armenian hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Herpes virus entry mediator, TR2, tumor necrosis factor receptor like 2, TNFRSF14
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