PE anti-mouse CD49b

CD49b is a 150 kD glycoprotein, also known as alpha2 integrin, VLA-2 alpha chain, Integrin alpha2 chain, and HMalpha2. It is a member of the integrin family, expressed on NK cells, a subset of splenic CD4+ T cells, NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, epithelial cells, and platelets. By associating with CD29 (integrin beta1 subunit), CD49b forms the VLA-2 (integrin alpha2beta1 ) complex. It plays a critical role in both adhesion and lymphocyte activation. The primary ligands for CD49b are collagen, laminin, and fibronectin. The HMalpha2 antibody has been shown to be useful for partially blocking CD49b mediated interactions with collagen. Additionally, this antibody blocks staining of splenic NK cells by the monoclonal antibody DX5.

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SPECIFICATIONS

Catalog Number

103506

Size

200 microg

Applications

FC

Hosts

Ham

Reactivities

Mouse

Clone

HMa2

Antigen

Mouse colon carcinoma cell line Colon26

Gene Id

16398

Isotype

Armenian Hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.06 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

alpha2 integrin, VLA-2 alpha chain, Integrin alpha2, HMa2

Regulatory Status

RUO