PE anti-mouse CD49d

CD49d is a 150 kD glycoprotein, also known as alpha4 integrin or VLA-4 alpha chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two beta chains, beta1 (CD29) or beta7, to form the VLA-4 (integrin alpha4beta1) or LPAM-1 (integrin alpha4beta7) complexes. CD49d plays a critical role in both adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin. The 9C10(MFR4.B) antibody, in combination with the R1-2 monoclonal antibody, completely blocks VCAM-1 binding to VLA-4.

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SPECIFICATIONS

Catalog Number

103705

Size

50 microg

Applications

FC

Hosts

Rat

Reactivities

Mouse

Clone

9C10 (MFR4.B)

Antigen

(C57BL/6 x A/J)F1 mouse fetal liver mas

Gene Id

16401

Isotype

Rat IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

alpha4 integrin, VLA-4 alpha chain, integrin a4

Regulatory Status

RUO