PE anti-mouse CD88 (C5aR)

Cat no: 135806

Supplier: BioLegend

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Description
Additional Information

CD88 is a single chain protein with seven membrane-spanning regions and a molecular weight of 43 kD. CD88 is expressed by neutrophils, eosinophils, and monocytes. There have been reports of CD88 expression in non-immune cells such as glial cells, cerebellar granule cells, cardiomyocytes, and vascular endothelial cells. CD88 is coupled to heterotrimeric G proteins such as Gi, and after C5a binding, the signal transduced by CD88 results in the activation of PLCbeta, PI-3 kinase, and PLA2, among other molecules, resulting in chemotaxis, granule enzyme release, and superoxide anion production.

Catalogue number:	135806
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry
Size:	200 microg
Clone:	20/70
Gene:	12273
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration:	0.2 mg/ml
Antigen:	mC5aR transfected cells
Isotype:	Rat IgG2b, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	C5a ligand, C5a anaphylatoxin receptor, C5AR, C5R1, C5AR1