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PE anti-mouse IFN-gamma R beta chain

PE anti-mouse IFN-gamma R beta chain

Cat no: 113603

Supplier: BioLegend
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IFN-gamma receptor beta chain is also known as IFN-gamma AF-1. This 60-65 kD class II cytokine receptor pairs with CDw119 to form the IFN-gamma receptor. CDw119 serves as the IFN-gamma-binding chain and associates with the IFN-gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN-gamma receptor alpha and beta chains must be species matched. The IFN-gamma receptor beta chain is expressed at low levels on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN-gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-gamma initiates and regulates a variety of immune responses.
Catalogue number: 113603
Reactivities: Mouse
Hosts: Hamster
Applications: Flow Cytometry
Size: 50 microg
Clone: MOB-47
Gene: 15978
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.2 mg/ml
Antigen: Mouse IFN-gammaR beta chain protein
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: IFN-gamma Receptor beta chain, IFN-gamma AF-1
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