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PE anti-mouse IL-22

PE anti-mouse IL-22

Cat no: 516404

Supplier: BioLegend
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IL-22 is a cytokine structurally related to IL-10. Mouse IL-22 consists of 179 amino acids and has a predicted molecular weight of 20 kD. It is secreted primarily by Th17, Th1, Th2, lymphoid tissue inducer cells (LTi), and subsets of natural killer cells. It has been reported that aryl hydrocarbon receptor (AhR) expression is essential for the production of IL-22 by TCRgammadelta T cells. AhR activation increases Th17 polarization and induces IL-22 production. IL-22 functions by engaging the heterodimeric IL-22 receptor (IL-22R) complex, consisting of two receptor subunits, IL-22R1 and IL-10Rbeta. IL-22 acts on nonhematopoietic tissue cells, such as epithelial cells of the digestive and respiratory systems and karatinocytes of the skin. IL-22 is involved in inflammatory processes such as dermal inflammation, psoriasis, inflammatory bowel disease, hepatitis, and crohn’s disease. Moreover, it plays a critical role in mucosal immunity and wound healing process.
Catalogue number: 516404
Reactivities: Mouse
Hosts: Goat
Applications: Flow Cytometry, Immunocytochemistry
Size: 100 tests
Clone: Poly5164
Gene: 50929
Dilutions: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 microl per million cells or 20 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen: Recombinant mouse IL-22
Isotype: Goat IgG
Clonality: Polyclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-22
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