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PE anti-mouse IL-27 p28

PE anti-mouse IL-27 p28

Cat no: 516908

Supplier: BioLegend
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Interleukin IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 P40-related protein) and P28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naïve CD4+ T cells, promotes Th1 polarization, and IFN-gamma production in synergy with IL-12. The IL-27 induced Th1 differentiation was mediated by rapid and marked up-regulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 has an anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation and a potential therapeutic role for autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rbeta2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27.
Catalogue number: 516908
Reactivities: Mouse
Hosts: Mouse
Applications: Flow Cytometry, Immunocytochemistry
Size: 100 microg
Clone: MM27-7B1
Gene: 246779
Dilutions: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.2 mg/ml
Antigen: Mouse IL-27-OVA
Isotype: Mouse IgG2a
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Interleukin-27 p28, IL-27-A, IL-27 subunit alp
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