PE anti-mouse Notch 3

Cat no: 130507

Supplier: BioLegend

0 reviews | Write a Review Pencil

Description
Additional Information

The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.

Catalogue number:	130507
Reactivities:	Mouse
Hosts:	Hamster
Applications:	Flow Cytometry
Size:	50 microg
Clone:	HMN3-133
Gene:	18131
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration:	0.2 mg/ml
Antigen:	Notch 3-Fc fusion protein
Isotype:	Armenian Hamster IgG
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4C
Alternative names:	Neurogenic locus notch homolog protein 3, Notch-3, Notch3, CADASIL, CASIL