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PE anti-mouse/rat/human FOXP3

PE anti-mouse/rat/human FOXP3

Cat no: 320007

Supplier: BioLegend
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FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 delta2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
Catalogue number: 320007
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Flow Cytometry, Immunocytochemistry
Size: 25 tests
Clone: 150D
Gene: 20371,317382,50943
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent intracellular staining with flow cytometric analysis. Test size products are transitioning from 20 microl to 5 microl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microl staining volume or per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
Storage buffer: The FOXP3 antibody solution should be stored undiluted at 4C, and protected from prolonged exposure to light. Do not freeze.
Antigen: Full-length FOXP3 protein
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2
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