PE/Cy7 anti-human CD194 (CCR4)

Cat no: 335405

Supplier: BioLegend

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CCR4 is a CC chemokine receptor, and it was clone from a human basophylic cell line KU-812 in 1995. (1). CCR4 binds CCL17 and CCL22 and is expressed on stimulated and unstimulated T, and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8 (2), and these receptors are regulated differently during Th2 development (3). Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4(-) Tregs require anti-CD3 Ab-mediated activation to acquire a regulatory activity. Depletion of CCR4(+) T cells leads to Th1-type polarization of CD4(+) T cells and augmentation of CD8(+) T cell responses to tumor Ags (4). CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases (5).

Catalogue number:	335405
Reactivities:	Human
Hosts:	Mouse
Applications:	Flow Cytometry
Size:	25 microg
Clone:	TG6/CCR4
Gene:	1233
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration:	0.2 mg/ml
Antigen:	Human CCR4 transfectants
Isotype:	Mouse IgG2b, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	CCR4, CC-CKR-4,CKR4

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PE/Cy7 anti-human CD194 (CCR4)

Cat no: 335405

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