PEBP2(beta) (R33) pAb

Cat no: BS2307

Supplier: Bioworld Technology, Inc.

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Additional Information

The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, (alpha) and (beta), which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2(alpha) subunits, PEBP2(alpha)A, PEBP2(alpha)B and PEBP2(alpha)C, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory (beta) subunit, which facilitates DNA binding of the (alpha) subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2(beta) is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2(beta)/CBF(beta)-SMMHC, that is associated with human acute myeloid leukemia.

Catalogue number:	BS2307
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q13951
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 2-56 of Human PEBP2(beta).
Species:	PEBP2(beta) (R33) pAb detects endogenous levels of PEBP2(beta) protein.
Molecular weight:	~ 22 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	CBFB; CBF-BETA; PEA2-BETA; PEBP2-BETA; PEBP2B
Additional info:	For research use only, not for use in diagnostic procedure.

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PEBP2(beta) (R33) pAb

Cat no: BS2307

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