Penicillin G is a broad based antibiotic used in mammalian cell culture. Penicillin G blocks the formation of bacterial cell walls, rendering bacteria unable to multiply and spread. The spectrum of activity of Penicillin G includes many aerobic and anaerobic gram-positive organisms. Aerobes susceptible to Penicillin G include most beta-hemolytic streptococci, beta-lactamase-negative staphylococci, Actinomyces species, some Bacillus anthracis, Corynebacterium species, and Erysipelothrix rhusiopathiae. Most species of anaerobes, including Clostridium species, but excluding beta-lactamase-producing Bacteroides species, are also susceptible to Penicillin G. Penicillin G is easily inactivated by beta-lactamases and has little efficacy against organisms that can produce these enzymes. In addition, Penicillin G is ineffective against those bacteria that are resistant by other mechanisms, such as having a relatively impermeable cell wall. Therefore, Penicillin G has little activity against many staphylococci and most gram-negative bacteria.
Appearance:
White to off white crystalline powder
Purity:
96-102.0%
Potency:
1500-1750u/mg
Identification:
Conforms to USP
Specific Rotation (C=0.7): +285 to +310 degrees
pH:
5.5-7.5
Loss on Drying:
(same/less than)1.0%
Absorbance:
264nm: As reported
280nm: As reported
325nm: As reported
Endotoxin:
<0.16U/mg
Related Substances: (same/less than)1.0%
2-Ethylhexanoic Acid:
(same/less than)0.5%
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