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PerCP/Cy5.5 anti-human CD192 (CCR2)

PerCP/Cy5.5 anti-human CD192 (CCR2)

Cat no: 335303

Supplier: BioLegend
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CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails (1). Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 has been associated to atheroscletotic plaques (2, 3). MCP-1 is induced by modified-LDL in endothelial cells, and may trigger firm adhesion of monocytes to vascular endothelium under flow. Local overexpression of MCP-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion (4). Absence of MCP-1 reduces the lesion size in MCP-1−/− apoE−/− mice in the apoE gene deleted mouse atherosclerosis model (5, 6). Obesity induces an inflammation state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation (7).
Catalogue number: 335303
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 25 tests
Clone: TG5/CCR2
Gene: 729230
Dilutions: Each lot of this CD192 antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PerCP/Cy5.5 has a maximum absorption of 482 nm and 564 nm and a maximum emission of 690 nm.
Storage buffer: The CD192 antibody solution should be stored undiluted at 4C, and protected from prolonged exposure to light. Do not freeze.
Antigen: CCR2 transfectants
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CCR2, CC-CKR-2
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