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PerCP/Cy5.5 anti-human LAP (TGF-beta1)

PerCP/Cy5.5 anti-human LAP (TGF-beta1)

Cat no: 349612

Supplier: BioLegend
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TGF-beta1 (transforming growth factor beta1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-beta. TGF-beta is synthesized as a large protein precursor and then secreted as a complex of TGF-beta and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-beta to prevent its activity. TGF-beta requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-beta binds to the integrins alphavbeta1, alphavbeta6, alphavbeta8, and alpha8beta1 through RGD domain. TGF-beta plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-beta is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.
Catalogue number: 349612
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100 tests
Clone: TW4-2F8
Gene: 7040
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PerCP/Cy5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen: LAP (TGF-beta)
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta, TGF-B1
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