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PF 184

Cat no: 019312


Supplier: United States Biological
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PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1b-induced TNF-a in a steroid-insensitive in vitro model of oxidative stress. Pfizer Compound
Catalogue number: 019312
Size: 10mg
Alternative names: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide;
References: Baldwin, A., et al.: J. Clin. Invest., 107, 3 (2001), Adcock, I., et al.: Eur. J. Pharmacol., 533, 118 (2006), Sommers, et al.: J. Pharmacol. Exp. Ther., 330 377 (2009),

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