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PGP9.5 (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, UCH-L1, Ubiquitin Thiolesterase L1, Neuron Cytoplasmic Protein 9.5, UCHL1)

Cat no: P9102-71N

PGP9.5 (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, UCH-L1, Ubiquitin Thiolesterase L1, Neuron Cytoplasmic Protein 9.5, UCHL1)

UCHL1 is a member of family of proteins that hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. The expression of UCHL1 is highly specific to neurons and to cell of the diffuse neuroendocrine system and their tumors. UCHL1 exhibits both and hydrolase and a ligase activity. The S18Y variant of UCHL1, that has reduced ligase activity, has been linked to susceptibility for Parkinson's disease.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9102-71N

Size

250ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human UCHL1.

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