PGRN Antibody

Cat no: 251319

Supplier: ABBIOTEC

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Description
Additional Information

Granulins are a family of secreted glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Progranulin (PGRN) is processed into granulin and then into a variety of active 6-kDa peptides (granulin A-G) that have possible cytokine-like activities with a role in inflammation, wound repair and tissue remodeling. Granulins are highly e, Xenopus/Amphibian,pressed in myelogenous leukemic cell lines of promonocytic,Porcineromyelocytic and proerythroid lineages. Defects in progranulin are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD), the second most common cause of dementia in people under the age of 65 years.

Catalogue number:	251319
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P28799
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human progranulin.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Granulins; Proepithelin; PEPI; Acrogranin; Paragranulin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin G; Granulin F; Granulin B; Granulin A; Granulin C; Granulin D; Granulin E; GRN; Progranulin; PGRN