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PHA-543613 Dihydrochloride

Cat no: 019334


Supplier: United States Biological
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PHA-543613 is a potent selective a7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype a7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer?s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays. Form: Tan Solid Melting Point: >300 degrees C Solubility: DMSO, Methanol Pfizer Compound
Catalogue number: 019334
Size: 10mg
Form: Tan Solid
Alternative names: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride; PHA 543613E;
References: Shaffer, C.L. et al.: Drug Metab. Dispos., 35, 1188 (2007); Wishka, D.G. et al.: J. Med. Chem., 49, 4425 (2006); Acker, B.A. et al.: Bioorg. Med. Chem. Lett., 18, 3611 (2008);

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