Phomopsin A

Phomopsin A is an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an "ansa" macrocycle with a three amino acid "tail", terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus Phomopsis leptostromiformis and is the causative agent of lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It acts by selectively binding to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Phomopsin A binds to tubulin at a site overlapping that of vinblastine and maytansine. Uniquely, phomopsin A protects tubulin from decay. \n\nSource: Phomposis leptostromiformis MST-FP2068\n\nApperance: Supplied as a white solid.\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water. \n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P3970

Size

1mg

Form

Supplied as a white solid

Purity

~98%

References

1. Structure elucidation and absolute configuration of phomopsin A, a hexapeptide mycotoxin produced by phomopsis leptostromiformis. Culvenor C. C. J. et al., Tetrahedron 1989, 45, 2351. 2. Interaction of phomopsin A and related compounds with purified sheep brain tubulin. E. Lacey et al., Biochem. Pharmacol. 1987, 36, 2133. 3. Interaction of phomopsin A with normal and subtilisin-treated bovine brain tubulin. Chaudhuri AR and Ludue