Phospho-CREB-1 (Ser133) Antibody

Cat no: 250813

Supplier: ABBIOTEC

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Description
Additional Information

The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA, a sequence present in many viral and cellular promoters. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1, ATF-2, ATF-3 and ATF-4. These transcription factors share highly-related COOH terminal leucine zipper dimerization and basic DNA binding but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in certain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recently been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265-kDa nuclear protein designated CBP (CREB-binding protein), which represents a CREB co-activator. Phosphorylation of Ser-133 is key for CREB transcriptional activity.

Catalogue number:	250813
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P16220
Antigen:	KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser-133 region of human CREB1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody
Isotype:	Rabbit Ig
Additional info:	cAMP response element-binding protein; CREB; CREB1