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Phospho-Tau Protein (Thr489) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 251362

Phospho-Tau Protein (Thr489) Antibody

Microtubule-associated protein tau (tau protein) promotes microtubule assembly and stability, and is involved in the establishment and maintenance of neuronal polarity. The C-terminus binds a, Xenopus/Amphibian,onal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. A, Xenopus/Amphibian,onal polarity is predetermined by tau localization in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms preferentially play a role in its stabilization. Hyperphosphorylation of the tau protein (tau inclusions,PorcineTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other tauopathies.

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SPECIFICATIONS

Catalog Number

251362

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Phospho-Tau Protein (Thr489).

Isotype

Rabbit Ig

Accession

P10636

Additional Info

Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; MAPT\nPHF-tau; MAPTL; MTBT1, TAU; Phospho-Tau Protein (Thr489)\n

SUPPLIER INFO

ABBIOTEC

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