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Phosphotyrosine

Cat no: P4078-36

Phosphotyrosine

Protein tyrosine phosphorylation has been the subject of intense investigation for over two decades. Tyrosine phosphorylation is catalyzed by members of the tyrosine kinase superfamily. To date, approximately 90 members of this superfamily have been identified in the human genome. Levels of phosphorylation of tyrosine residues within cellular proteins are observed to increase in response to growth factors, cytokines, insulin, extracellular matrix components, and other stimuli. Tyrosine phosphorylation has several effects, including the regulation of enzyme activity, as well as the localization of enzyme activity through the generation of docking sites for proteins bearing SH2 domains.\n\nApplication(s): \nELISA \nImmunoprecipitation \nWestern Blot \nOptimal conditions must be determined individually for each application.\n\nPOSITIVE CONTROL INCLUDED: \nYes.\n

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SPECIFICATIONS

Catalog Number

P4078-36

Size

50ug

Applications

ELISA, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Can

Form

Supplied as a liquid in PBS, 0.09% sodium azide, PEG, sucrose.

P Type

Mab

Purity

Purified by subsequent thiophilic absorption and size exclusion chromatography.

Isotype

IgG1

Additional Info

Recognizes tyrosine-phosphorylated peptides. Species Crossreactivity: Human, Mouse, Rat, Dog

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