Supplier:
Alomone Labs Ltd.Cat no: P-710
Phrixotoxin-1
Phrixotoxin 1 (PaTx1) is a 29 amino acid peptidyl toxin isolated from the venom of the theraphosid Phrixotrichus auratus, which potently blocks A-type K+ currents.
PaTx1 specifically blocks Kv4.3 and Kv4.2 currents with a 5 nM < IC50 < 70 nM, by modifying the gating properties of these channels.
As with other spider toxins, PaTx1 presents an active molecular surface, including a hydrophobic patch surrounded by charged residues, which are important for their binding on Kv channels. Electrophysiological studies show that the PaTx1 blocks Kv4 channels via a mechanism similar to that of hanatoxins on Kv2 channels, as they bind and stabilize the preferentially closed state of the channel, in a voltage-dependent manner.
PaTx1 is a crucial tool for understanding the contribution of Kv4.3 and Kv4.2 in cardiac electrogenesis. Treatment of mice with PaTx1 results in numerous transient cardiac adverse reactions including the occurrence of premature ventricular beats, ventricular tachycardia, different degrees of atrioventricular (AV) blockage and prolongation of the QT interval.
Alomone Labs is pleased to offer Phrixotoxin-1, a natural peptide purified to homogeneity from the venom of the tarantula phrixotrichus auratus
Ion Channel Modulators; K+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
P-710
Size
5 x 5 micro g
Purity
>98%
Concentration
10-100 nM.
Shipping Temp
Room Temperature
Molecular Weight
3549 da
SUPPLIER INFO
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