Phrixotoxin-3. Potent Blocker�of Nav1.2 Channel.
Phrixotoxin-3 is a native peptidyl toxin isolated from the venom of the tarantula Phrixotrichus auratus This toxin is a highly specific and potent blocker of voltage-gated Na+channels, especially the neuronal channel Nav1.2, with properties similar to those of typical gating-modifier toxins by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current.
Injection of phrixotoxin-3 to mice causes neurotoxicity symptoms that are expressed by general ataxia, lack of response to stimuli, and semiparalysis.
Alomone Labs is pleased to offer Phrixotoxin-3, a natural native toxin purified to homogeneity from the venom of the tarantula Phrixotrichus auratus
Ion Channel Modulators;K Voltage - Gated Na+ Channel Blockers.
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