Supplier:
Alomone Labs Ltd.Cat no: P-145
Pilsicainide hydrochloride
Voltage-gated sodium channels (VGSC, Nav) are critically important for electrogenesis and nerve impulse conduction. Certain sodium channel isoforms are predominantly expressed in peripheral sensory neurons associated with pain sensation, and the expression and functional properties of Nav in peripheral sensory neurons can be dynamically regulated following axonal injury or peripheral inflammation.
Pilsicainide is a class IC anti-arrhythmic drug widely used in the treatment of supraventricular and ventricular tachyarrhythmias in Japan.
Results from voltage clamp experiments show that Pilsicainide is a pure sodium channel blocker with little or no effect on other cardiac channels, probably with the exception of HERG channels.
Measurements of PilsicainideпїЅs ability to block hNav1.4 channels resulted in half-maximum inhibitory concentrations (IC50) of 189 пїЅ 10 μM at 0.1 Hz, and 76 пїЅ 7 μM at 10 Hz. Effects of Pilsicainide were similar on skeletal muscle hNav1.4, brain hNav1.1 and heart hNav1.5 channels.
Ion Channel Modulators; Voltage-Gated Na+ Channel Blockers
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SPECIFICATIONS
Catalog Number
P-145
Size
5 mg
Purity
>98%
Concentration
10-200 uM
Shipping Temp
Room Temperature
Molecular Weight
272.3 Da
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