Home  >  Products  >  PINX1 (PIN2/TERF1-interacting Telomerase Inhibitor 1, Liver-related Putative Tumor Suppressor, Pin2-interacting Protein X1, Protein 67-11-3, TRF1-interacting Protein 1, LPTL, LPTS)
PINX1 (PIN2/TERF1-interacting Telomerase Inhibitor 1, Liver-related Putative Tumor Suppressor, Pin2-interacting Protein X1, Protein 67-11-3, TRF1-interacting Protein 1, LPTL, LPTS)

PINX1 (PIN2/TERF1-interacting Telomerase Inhibitor 1, Liver-related Putative Tumor Suppressor, Pin2-interacting Protein X1, Protein 67-11-3, TRF1-interacting Protein 1, LPTL, LPTS)

Cat no: P4193-01B

Supplier: United States Biological
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Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Western Blot: 1-3ug/ml, Jurkat lysate observed on ~35kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P4193-01B
Reactivities: Human, Mouse, Rat, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Zhou XZ, Lu KP. Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 2001 Nov 2;107(3):347-59.
Additional info: Recognizes human PINX1. Species sequence homology: Bovine, canine, mouse, porcine and rat.

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