Pirh2 (1H10) Antibody

Cat no: 252965

Supplier: ABBIOTEC

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Description
Additional Information

Pirh 2 (P53 induced RING-H2 protein) mediates E3-dependent ubiquitination and proteasomal degradation of proteins. Pirh2 has ubiquitin-protein ligase activity and binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 e, Xenopus/Amphibian,pression decreases the level of p53, and a decrease of endogenous Pirh2 e, Xenopus/Amphibian,pression increases p53 levels. Pirh2 is therefore considered together with MDM2, to act as a negative regulator of p53 function.

Catalogue number:	252965
Reactivities:	Human, Rabbit
Applications:	Flow Cytometry, Immunofluorescence
Size:	0.1 ml
Accession:	Q96PM5
Antigen:	Purified recombinant fragment of human Pirh2 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	1H10
Additional info:	RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; Zinc finger protein 363; p53-induced RING-H2 protein; hPirh2; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RCHY1