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PKA(alpha)/(beta) cat (V191) pAb

PKA(alpha)/(beta) cat (V191) pAb

Cat no: BS1576

Supplier: Bioworld Technology, Inc.
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The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated C(alpha), C(beta) and C(gamma), that each represent specific gene products. C(alpha) and C(beta) are closely related (93% amino acid sequence similarity), whereas C(gamma) displays 83% and 79% similarity to C(alpha) and C(beta), respectively.
Catalogue number: BS1576
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P17612/P22694
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 160-210 of Human PKA(alpha).
Species: PKA(alpha)/(beta) cat (V191) pAb detects endogenous levels of PKA(alpha)/(beta) protein.
Molecular weight: ~ 40, 42 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACA; PKACA; PKA Ca; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; PRKACB; PKACB; PKA Cb;
Additional info: For research use only, not for use in diagnostic procedure.

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