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PLC (beta)2 pAb

PLC (beta)2 pAb

Cat no: BS5860

Supplier: Bioworld Technology, Inc.
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Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC (beta)1, PLC (beta)2, PLC (beta)3, PLC (beta)4, PLC (gamma)1, PLC (gamma)2, PLC (delta)1,PLC (delta)2 and PLC E). PLC (beta)s are the only PLC isforms that are regulated by G protein subunits and are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Two alternatively spliced forms (1,181 and 1,166 amino acids) of PLC (beta)2 are generated in hematopoietic cells that differ in the carboxyl-terminal sequence implicated in interaction of PLC (beta) enzymes with G(alpha)q.The pleckstrin homology domain of PLC (beta)2 is required for its targeting to the membrane and for substrate hydrolysis and its linker region exerts an inhibitory efect on basal PLC (beta)2 activity. PLC (beta)2 plays a major role in platelet activation and is mainly expressed in the periphery of the islet and acinar cells in rat pancreas.
Catalogue number: BS5860
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q00722
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 382-427 of Human PLC (beta)2.
Species: PLC (beta)2 pAb detects endogenous levels of PLC (beta)2 protein.
Molecular weight: ~ 133 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2; PLC-(beta)2; PLC(beta)2; PLC-(beta)-2; PLC (beta)-2; PLC(beta)-2
Additional info: For research use only, not for use in diagnostic procedure.

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