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PLC (gamma)2 pAb

PLC (gamma)2 pAb

Cat no: BS6693

Supplier: Bioworld Technology, Inc.
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Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC (beta)1, PLC (beta)2, PLC (beta)3, PLC (beta)4, PLC (gamma)1, PLC (gamma)2, PLC ?1, PLC ?2 and PLC e. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC (gamma)2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR (gamma) chain), which bind to its C-terminal SH2 domain. PLC (gamma)1 associates with Syk in B cells, but PLC (gamma)2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC (gamma)2. In addition, Btk can induce PLC (gamma)2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Catalogue number: BS6693
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P16885
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human PLC (gamma)2.
Species: PLC (gamma)2 pAb detects endogenous levels of PLC (gamma)2 protein.
Molecular weight: ~ 148 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2; PLCG2; PLC(gamma)2; PLC-(gamma)2; PLC (gamma)-2
Additional info: For research use only, not for use in diagnostic procedure.

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