Pleuromutilin (Drosophilin B, Antibiotic A 40104C)

Pleuromutilin is a diterpene produced by several species of basidomycetes, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin. \n\nSource: Pleurotus sp. MST-FP2115A\n\nApperance: White solid\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P4270-90

Size

25mg

Purity

~95%

References

1. Antibiotic substances from basidomycetes. VIII. Pleurotus mutilus (Fr.) Sacc. & Pleurotus passeckerianus Pilat. Kavanagh F. et al., Proc. Natl. Acad. Sci. USA 1951, 37, 570. 2. Pleuromutilin antibiotics. Hunt E., Drugs Future 2000, 25, 1163. 3. Pleuromutilins. Part 1. The indentification of novel mutilin 14-carbamates. Brooks G. et al., Bioorg. Med. Chem. 2001, 9, 1221.