PLGF2, Recombinant, Human (Placental Growth Factor 2)

Placenta growth factor (PlGF), a homodimeric glycoprotein that is homologous to vascular endothelial growth factor (VEGF), is mitogenic to endothelial cells and protects trophoblast from apoptosis. Alternative splicing of mature mRNA gives rise to three known isoforms of PlGF. PlGF is expressed by human trophoblast during normal pregnancy, however, it is not known which isoforms are produced.\n\nRecombinant Human PLGF-2 produced in insect cells is a homodimer comprised of glycosylated polypeptide chains containing 2 x 152 amino acids and having a total molecular mass of 44kD. Recombinant Human PLGF-2 is purified by proprietary chromatographic techniques\n\nBiological Activity: \nBiologically active when compared to standard. Can bind to immobilized rh-sFlt-1 (100ng/well) with a linear range at 0.3-10ng/ml corresponding to a specific activity of 0.1-3.4 MIU/mg.\n\nStorage and Stability: \nLyophilized human PLGF-2 although stable at room temperature for 3 weeks, should be stored desiccated below -20 degrees C. Upon reconstitution human PLGF-2 may be stored at 4 degrees C for up to 7 days and for long-term storage, in aliquots at -20 degrees C. Please avoid freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

P4273-20

Size

2ug

Form

Supplied as a lyophilized powder containing BSA. Reconstitute in sterile 20mM acetic acid to a concentration of (same/more than)100ug/ml, which can then be further diluted to other aqueous solutions.

Purity

(same/more than)80% as determined by RP-HPLC and SDS-PAGE