PML (P39) Peptide

Cat no: BS1296P

Supplier: Bioworld Technology, Inc.

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Additional Information

The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal trans-location of the retinoic acid receptor alpha (RARalpha) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARalpha chimeric protein. Myeloid precursor cells expressing the PML/ RARalpha chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RARalpha transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/ RARalpha also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.

Catalogue number:	BS1296P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P29590
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide PML (P39). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	PML; MYL; PP8675; RNF71; TRIM19
Additional info:	This peptide can be used with studies using BS1296 PML (P39) pAb.

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PML (P39) Peptide

Cat no: BS1296P

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