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POLR3H, Recombinant, Human, aa1-204, His-Tag (DNA-directed RNA Polymerase III Subunit RPC8, RPC22.9, RPC8)

Cat no: 138717

POLR3H, Recombinant, Human, aa1-204, His-Tag (DNA-directed RNA Polymerase III Subunit RPC8, RPC22.9, RPC8)

POLR3H, also as known as A1665 and RPC8, belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family. POLR3H is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. POLR3H acts as nuclear and cytosolic DNA sensor involved in innate immune response. \n\nSource:\nRecombinant protein corresponding to aa1-204 from human POLR3H at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~25.3kD (227aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGS TKVHFRCVVF HPFLDEILIG KIKGCSPEGV HVSLGFFDDI LIPPESLQQP AKFDEAEQVW VWEYETEEGA HDLYMDTGEE IRFRVVDESF MFVLVEM VDTVRIPPWQ FERKLNDSIA EELNKKLANK VVYNVGLCIC LFDITKLEDA YVFPGDGASH VDTSPTGPSS ADATTSSEEL PKKEAPYTLV GSISEPGLGL LSWWTSN\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138717

Size

100ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.1M sodium chloride, 1mM DTT, 10% glycerol.

Purity

~90% (SDS-PAGE)

References

1. Ablasser A., et al. (2009) Nat. Immunol. 10:1065-1072 2. Hu P., et al. (2002) Mol. Cell. Biol. 22:8044-8055.

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