Polyclonal Anti-ABCC1

Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 1 (ABCC1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1634

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

ABCC1

References

1. Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654, 1992.\n2. Conrad, S., Kauffmann, H.-M., Ito, K., Deeley, R. G., Cole, S. P. C., Schrenk, D. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution. J. Hum. Genet. 46: 656-663, 2001.\n3. Grant, C. E., Kurz, E. U., Cole, S. P. C., Deeley, R. G. Analysis of the intron-exon organization of the uman multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA. Genomics 45: 368-378, 1997.\n

Swiss Prot

P33527

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of human ABCC1, different from the related rat and mouse sequences by one amino acid.

Scientific Background

ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1),also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene. The ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. The ABCC1 is a plasma membrane drug-efflux pump.The ABCC1 gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking ABCC1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that ABCC1 is an important protector in this scenario. ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine.And Chemotaxis assays show that ABCC1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.