

Supplier:
BOSTER IMMUNOLEADERCat no: PA1504
Polyclonal Anti-BCL10
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SPECIFICATIONS
Price
200.00 USD
Catalog Number
PA1504
Size
100ug/vial
Applications
WB
Reactivities
Hum, Mouse, Rat
Form
Lyophilized
Format
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Gene Id
BCL10
References
1. Ruland, J., Duncan, G. S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A., Ohashi, P. S., Mak, T. W.Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappa-B and neural tube closure.Cell 104: 33-42, 2001.\n2. Willis, T. G., Jadayel, D. M., Du, M.-Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P. G., Dyer, M. J. S.Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor typesCell 96: 35-45, 1999.\n3. Xue, L., Morris, S. W., Orihuela, C., Tuomanen, E., Cui, X., Wen, R., Wang, D.Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.Nature Immun. 4: 857-865, 2003.\n
Swiss Prot
O95999
Storage Temp
\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n
Additional Info
A synthetic peptide corresponding to a sequence at the N-terminal of human BCL10, identical to the related rat and mouse sequences.
Scientific Background
BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22 The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
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