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Products Polyclonal Anti-BOC
| Catalogue number: | PA1904 |
| Price: | $200.00 |
| Reactivities: | Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | BOC |
| Swiss prot: | Q6AZB0 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | BOC(Brother Of CDO) also known as BROTHER OF CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail. The domain structure of BOC is similar to that of CDON, and the 2 proteins share 38 to 80% amino acid identity in the individual extracellular domains. The International Radiation Hybrid Mapping Consortium mapped the BOC gene to chromosome 3. In contrast with CDON, the intracellular region of BOC was not essential for its ability to positively regulate differentiation.BOC is dependent on CDON for activity and that CDON-BOC complexes function to regulate myogenic differentiation. Wegorzewska et al. (2003) proposed that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage.BOC is expressed by commissural neurons, and targeted disruption of BOC in mouse resulted in the misguidance of commissural axons toward the floor plate. |
| References: | 1. Kang, J.-S., Mulieri, P. J., Hu, Y., Taliana, L., Krauss, R. S. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 21: 114-124, 2002. 2. Okada, A., Charron, F., Morin, S., Shin, D. S., Wong, K., Fabre, P. J., Tessier-Lavigne, M., McConnell, S. K. Boc is a receptor for Sonic hedgehog in the guidance of commissural axons. Nature 444: 369-373, 2006. 3. Wegorzewska, M., Krauss, R. S., Kang, J.-S. Overexpression of the immunoglobulin superfamily members CDO and BOCenhances differentiation of the human rhabdomyosarcoma cell line RD. Molec. Carcinogen. 37: 1-4, 2003. 1. Kang, J.-S., Mulieri, P. J., Hu, Y., Taliana, L., Krauss, R. S. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 21: 114-124, 2002. 2. Okada, A., Charron, F., Morin, S., Shin, D. S., Wong, K., Fabre, P. J., Tessier-Lavigne, M., McConnell, S. K. Boc is a receptor for Sonic hedgehog in the guidance of commissural axons. Nature 444: 369-373, 2006. 3. Wegorzewska, M., Krauss, R. S., Kang, J.-S. Overexpression of the immunoglobulin superfamily members CDO and BOCenhances differentiation of the human rhabdomyosarcoma cell line RD. Molec. Carcinogen. 37: 1-4, 2003. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of mouse BOC, identical to the related rat sequence. |
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