Polyclonal Anti-CCR7

Rabbit IgG polyclonal antibody for C-C chemokine receptor type 7 (CCR7) detection. Tested with WB in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1017

Size

100ug/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CCR7

References

1. Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy RL Jr, Shows TB, Gray PW. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics.1994 Oct; 23(3):643-50.\n2. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A.Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999 Oct 14; 401(6754):708-12.

Swiss Prot

P32248

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminal of rat CCR7(347-363aa LSQERLRQWSSCRHVRH), different from the related mouse sequence by one amino acid, and from human sequence by two amino acids

Scientific Background

Schweickart et al.identified CCR7(also known as EBI1) in 1994, which is a lymphoid-specific member of the G protein-coupled receptor family. This gene, which is encoded on human chromosome 17q12-q21.2, is expressed in normal lymphoid tissues and in several B- and T-lymphocyte cell lines with 86% identity to the mouse homolog. It is also related to the receptors that recognize chemoattractants, such as interleukin-8, RANTES, C5a, and fMet-Leu-Phe. Expression of CCR7 controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets.