Polyclonal Anti-CD86

Rabbit IgG polyclonal antibody for T-lymphocyte activation antigen CD86 (CD86) detection. Tested with WB in Mouse. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1394

Size

100ug/vial

Applications

WB

Reactivities

Mouse

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CD86

References

1. Chen C, Gault A, Shen L, Nabavi N (May 1994). \"Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule\". J. Immunol. 152 (10): 4929

Swiss Prot

P42082

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of mouse CD86, different from the related rat sequence by 2 amino acids

Scientific Background

CD86 is officially called Cluster of Differentiation 86, also known as B7-2. Being a member of the immunoglobulin superfamily, it is a protein expressed on antigen-presenting cells. The CD86 gene is mapped to human chromosome 3q21. The smallest transcript, 828 bp, which the authors termed CD86deltaTM, has a deletion from nucleotide 686 to nucleotide 829 (i.e., exon 6) and encodes a 275-amino acid protein. CD86deltaTM enhances proliferation and cytokine production by both naive and memory T cells, providing costimulatory signals necessary for T cell activation and survival.