Polyclonal Anti-CDC25A

Rabbit IgG polyclonal antibody for M-phase inducer phosphatase 1 (CDC25A) detection. Tested with WB, IHC-P in Human;Mouse;Rat. \n

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA1545

Size

100ug/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CDC25A

References

1. Demetrick, D. J., Beach, D. H.Chromosome mapping of human CDC25A and CDC25B phosphatases.Genomics 18: 144-147, 1993.\n2. Galaktionov, K., Lee, A. K., Eckstein, J., Draetta, G., Meckler, J., Loda, M., Beach, D.CDC25 phosphatases as potential human oncogenes.Science 269: 1575-1577, 1995.\n

Swiss Prot

P30304

Storage Temp

\"At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.\nAvoid repeated freezing and thawing. \n\"\n

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human CDC25A, identical to the related rat and mouse sequence.

Scientific Background

The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphate from tyrosine and threonine residues of the cyclin-dependent kinases.The genes encoding these phosphatases are suspected of being potential oncogenes because of their role in promoting cell division. Three human CDC25 genes have been identified: CDC25A, CDC25B , and CDC25C . The CDC25A gene is mapped to 3p21 .in rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either the gly12-to-val mutation of the HRAS gene or loss of RB1 in oncogenic focus formation.