Polyclonal Anti-CHRM1

Rabbit IgG polyclonal antibody for Muscarinic acetylcholine receptor M1 (CHRM1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2202

Size

100?g/vial

Applications

IHC, WB

Reactivities

Hum, Mouse, Rat

Form

lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

CHRM1

References

1. Anagnostaras, S. G., Murphy, G. G., Hamilton, S. E., Mitchell, S. L., Rahnama, N. P., Nathanson, N. M., Silva, A. J. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nature Neurosci. 6: 51-58, 2003.\n2. Knox, S. M., Lombaert, I. M. A., Reed, X., Vitale-Cross, L., Gutkind, J. S., Hoffman, M. P. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science 329: 1645-1647, 2010.\n

Swiss Prot

P11229

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the C-terminus of human CHRM1, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Scientific Background

Muscarinic acetylcholine receptor M1, also known as cholinergic receptor, muscarinic 1, is a muscarinic receptor. This gene is mapped to 11q12.3. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.